U-editing-enzyme-APOBEC-1(APOBEC1)-11089.html" />

在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human C->U-editing enzyme APOBEC-1 (APOBEC1)

Recombinant Human C->U-editing enzyme APOBEC-1 (APOBEC1)

  • 中文名稱：
    Recombinant Human C->U-editing enzyme APOBEC-1(APOBEC1)
  • 貨號：
    CSB-YP001919HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human C->U-editing enzyme APOBEC-1(APOBEC1)
  • 貨號：
    CSB-EP001919HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human C->U-editing enzyme APOBEC-1(APOBEC1)
  • 貨號：
    CSB-EP001919HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human C->U-editing enzyme APOBEC-1(APOBEC1)
  • 貨號：
    CSB-BP001919HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human C->U-editing enzyme APOBEC-1(APOBEC1)
  • 貨號：
    CSB-MP001919HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    APOBEC1
  • Uniprot No.：
  • 別名：
    ABEC1_HUMAN; APOBEC 1; APOBEC1; Apolipoprotein B mRNA editing enzyme; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 1; Apolipoprotein B mRNA editing enzyme complex 1; Apolipoprotein B mRNA-editing enzyme 1; BEDP; C->U-editing enzyme APOBEC-1; CDAR1; EC 3.5.4.; HEPR
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-236
  • 氨基酸序列
    MTSEKGPSTG DPTLRRRIEP WEFDVFYDPR ELRKEACLLY EIKWGMSRKI WRSSGKNTTN HVEVNFIKKF TSERDFHPSM SCSITWFLSW SPCWECSQAI REFLSRHPGV TLVIYVARLF WHMDQQNRQG LRDLVNSGVT IQIMRASEYY HCWRNFVNYP PGDEAHWPQY PPLWMMLYAL ELHCIILSLP PCLKISRRWQ NHLTFFRLHL QNCHYQTIPP HILLATGLIH PSVAWR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
  • 基因功能參考文獻：
    1. Our findings propose APOBEC1 and isoform b as the potential endogenous mutators implicated in cancer in-frame indels and pave the way for their use as novel prognostic tumor markers. PMID: 29346513
    2. Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells. PMID: 28639893
    3. AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review) PMID: 26398702
    4. Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models. PMID: 25085003
    5. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in esophageal squamous cell carcinoma. PMID: 25839328
    6. hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
    7. Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4). PMID: 19911124
    8. The hypermutation activity of APOBEC-1 was decreased to background levels by a single point APOBEC-1 mutation of P29F or E181Q, while 50% of wild-type control editing at the normal site was retained. PMID: 20348446
    9. The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation. PMID: 19932086
    10. expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing PMID: 11815617
    11. determination of multifunctional cycle and suppression of nonsense-mediated decay PMID: 12881431
    12. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling PMID: 12896982
    13. apobec-1-mediated apoB mRNA editing is regulated by BAG-4 PMID: 14559896
    14. Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48. PMID: 15979078
    15. APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase PMID: 16999936
    16. No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected. PMID: 17696929
    17. Demonstrates the presence of a 36-aa peptide (isoform 2) derived from this gene in adult small intestinal villi using immunocytochemical analysis. PMID: 9186903

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cytidine and deoxycytidylate deaminase family
  • 組織特異性：
    Expressed exclusively in the small intestine.
  • 數據庫鏈接：

    HGNC: 604

    OMIM: 600130

    KEGG: hsa:339

    STRING: 9606.ENSP00000229304

    UniGene: Hs.560



主站蜘蛛池模板： 一本色道无码道在线观看| 国产精品爽爽v在线观看无码| 欧美性videos高清精品| 无码熟熟妇丰满人妻啪啪| 国产亚洲中文字幕在线制服| 日韩无套无码精品| 好湿好紧太硬了我太爽了视频| 在线观看麻豆国产成人av在线播放 | 国产免费看插插插视频| 西西人体大胆4444www| 久久久久四虎精品免费入口| 激情综合丁香五月| www国产精品内射老师| 色欲色香天天天综合无码| 国内丰满熟女出轨videos| 亚洲欧美综合区自拍另类| 精品久久久无码中文字幕边打电话| 亚洲欧洲无码av电影在线观看| 久久久久久综合岛国免费观看| 国产农村老太xxxxhdxx| 久久久无码人妻精品一区| 国产在线乱码一区二区三区| 日韩人妻无码免费视频一区二区| 少妇被爽到高潮动态图| 国产成av人片在线观看天堂无码| 一本无码中文字幕在线观| 曰本av中文字幕一区二区 | 欧美巨大巨粗黑人性aaaaaa| 99久久精品国产一区二区三区| 久99视频精品免费观看福利| 7777色鬼xxxx欧美色妇| 亚洲精品成人久久久| 国产成人啪精品视频免费网站软件 | 国产高清乱理伦片| 国产手机在线无码播放视频| 无码乱人伦一区二区亚洲一| 亚洲系列一区中文字幕| 久久只精品99品免费久23| 曰韩内射六十七十老熟女影视| 免费无码av片在线观看动漫| 欧美人妻久久精品|